In 2261, the Vorlons join the Shadow War, but their tactics become a concern for the alliance when the Vorlons begin destroying entire planets which they deem to have been "influenced" by the Shadows. Disturbed by this turn of events, Babylon 5 recruits several other powerful and ancient races (the First Ones) to their cause, against both the Shadows and the Vorlons. Captain John Sheridan returns to the station after escaping from Z'ha'dum, but at a price: barring illness or injury, he has only 20 years left to live. He is accompanied by a mysterious alien named Lorien who claims to be the oldest sentient being in the galaxy.
Hours before Sheridan's return, Garibaldi is rescued and returned to the station, in rather dubious circumstances. He is markedly more paranoid and suspicious of other alien races and of Sheridan than he was before.
Centauri Emperor Cartagia forges a relationship with the Shadows. Londo Mollari engineers the assassination of Cartagia and repudiates his agreement with the Shadows. Londo kills Mr. Morden and destroys the Shadow vessels based on the Centauri homeworld, in an attempt to save his planet from destruction by the Vorlons. Aided by the other ancient races, and several younger ones, Sheridan lures both the Vorlons and the Shadows into an immense battle, during which the Vorlons and Shadows reveal that they have been left as guardians of the younger races, but due to philosophical differences, ended up using them as pawns in their endless wars throughout the ages. The younger races reject their continued interference, and the Vorlons and Shadows, along with the remaining First Ones, agree to depart the galaxy forever.
After the Shadows are defeated Garibaldi leaves his post as security chief and works on his own as a "provider of information". He begins working for one William Edgars, a Mars Tycoon, who is married to Garibaldi's former love. While he works ever closer with Edgars, he becomes increasingly aggressive towards Sheridan and eventually leaves Babylon 5.
Minbar is gripped by a brief civil war between the Warrior and Religious castes. Delenn secretly meets with Neroon of the Warrior caste and convinces him that neither side can be allowed to win. She tells him that she will undergo a ritual wherein she will be willing to sacrifice herself, but will stop the ritual before she actually dies. When Neroon sees that she actually intends to go through the entire ritual, he rescues her and sacrifices himself instead, declaring that, although he was born Warrior, in his heart he is Religious.
As part of the ongoing conflict between Earth and Babylon 5, Garibaldi eventually betrays Sheridan and arranges his capture in order to gain Edgars' trust and learn his plans. Garibaldi later learns that Edgars created a virus that is dangerous to only telepaths. It is then revealed, that Garibaldi was actually abducted by the Psi-Corps at the end of Season 3 and re-programmed by Bester to provide information to him at the right time. Bester releases Garibaldi of his programming, and allows him to remember everything he has done since being kidnapped. Edgars is killed and his wife disappears, but is reunited with Garibaldi after the end of the war. Garibaldi helps free Sheridan and return him to the campaign to free Earth. An alliance led by Babylon 5 frees Earth from totalitarian rule by President Clark in a short but bloody war. This culminates in Clark's suicide and the restoration of democratic government. Mars is granted full independence, and Sheridan agrees to resign his commission. The League of Non-Aligned Worlds is dissolved and reformed into the Interstellar Alliance, with Sheridan elected as its first President and continuing his command of the Rangers, who are to act as a galactic equivalent of United Nations peacekeepers.
In the season finale, the events of 100, 500, 1000, and one million years into the future are shown, depicting Babylon 5's lasting influence throughout history. Amongst the events shown are the political aftermath of the 2261 civil war, a subsequent nuclear war on Earth involving a new totalitarian government in the year AD 2762, the resulting fall of Earth into a pre-industrial society, the loss and restoration of humanity's knowledge of space travel, and the final evolution of mankind into energy beings similar to the Vorlons, after which Earth's sun goes nova.
0.01983已完结主演:罗伯特·米彻姆,艾丽·麦古奥,冉-迈克尔·文森特,约翰·豪斯曼,波莉·伯根,莉莎·埃尔巴赫,大卫·杜克斯,托波尔,本·墨菲,皮特·格拉维斯,杰瑞米·坎普,拉尔夫·贝拉米,维多利亚·田纳特,沃尔夫冈·普莱斯,威廉·伍德森,昆特·迈斯纳,赖因哈德·科尔德霍夫,Werner Kreindl,Rainer Penkert,Alexander Kerst,约阿希姆.汉森,Dragomir Stanojevic-Bata Kameni,安东·迪夫伦,巴瑞·摩司,John Carter,黛博拉·温特斯,罗伊·普尔,艾伦
0.02025更新至第14集主演:杨旭文,杨志刚,郜思雯,陈创,孙雪宁,石悦安鑫
0.02025更新至第39集主演:丁一宇,郑仁仙,李泰兰,尹贤旻,千虎珍,潘孝贞,尹周相,金姬贞,朴成根,金正英
0.02025已完结主演:马特·史密斯,莎拉·格林,拉斐尔·马特,约翰·迈尔斯,罗伯特·格林尼斯特,爱丽丝·菲塔姆,琳赛·邓肯,尼克·凯夫,大卫·斯瑞弗,帕特里克·卡斯韦尔,安德鲁·麦克莱,亚历山大·莱利,弗朗西斯·托姆利,奥拉米德·坎迪德-约翰逊,查莉·邓肯,吉玛·戴伦,安娜·克里帕,娜塔莉·沃尔特,提莉·沃克,波比·瑞恩斯伯里,杰妮·哈克曼,肯特·古德芬奇,劳拉·多丁顿,爱德华E.沃特,Olivia Brady,Lydia Hunt,Keshini Misha,Andrea Valls
0.02025已完结主演:间宫祥太朗,新木优子,森本慎太郎,深川麻衣,户塚纯贵,刚力彩芽,木村昴,藤间爽子,工藤阿须加,松井玲奈,稻叶友,森优作,水川航大,德永绘里,木津翼,玉田志织,秋谷郁甫,田中美久,宫崎莉里沙,矢柴俊博,赤间麻里子,野林万稔,鈴木礼彩,渡边斗翔,川野結太,湊,本屋碧美,森优理斗,松岡夏輝,和田爱海,渡邉櫂,荒木美緒,三上野乃花,三多海翔,保坂凛駆,山﨑莞那,安友早良,眞野煌汰,長三伊乃,愛由,弘中杏,小川拓真,有田一花,西村優里花,古澤利空,岡本恭太郎,中村龍太郎,岩本佳子,飯田正,石切山莉央
0.02025更新至第01集主演:福田知盛,保罗·贝坦尼,加布瑞拉·克里维,奥莉维亚·米娅·贝瑞特,奥尔索雅·赫莱提亚,克里斯蒂安·切尔,理查德·科尔文,罗德里克·希尔,费利克斯·乌夫,西丹特·阿南德,阿黛尔·托德,尤娜·科瓦奇,卡蒂亚·博科尔,罗里·金尼尔,鲁珀特·范西塔特,乔纳森·阿里斯,露西·科乎,保罗·巴泽利,杰西卡·亚历山大,休·萨克斯
0.02025更新至第10集主演:江奇霖,章宇,尹正,兰西雅,韩静 ,蒋奇明,甘昀宸,周政杰,艾丽娅,安沺,董牧沙,宋家腾
0.02025更新至第24集主演:虞书欣,何与,吴翊歌
0.02025更新至第12集主演:高伟光,梁靖康,张淼怡,毛晓慧,张宸逍,王宥钧,戴向宇,戴蕥琪,古子成,何雨虹,汤梦佳,厉嘉琪,赵尧珂,彭楚粤,姬晓飞,王伊瑶,姚一奇,宋涵宇,沈浩,丁笑滢,刘萌萌,岳旸,费启鸣,翁虹,张琪,于谨维,魏子昕,杜奕衡,罗二羊,王建国
0.02025更新至第24集主演:成毅,刘奕君,王劲松,周奇,佟梦实,徐璐,倪大红,张涵予,叶祖新,成泰燊,黄觉,韩童生,尹铸胜,宋佳伦,边程,李宗翰,张晓谦,陈姝君,王子璇,王祖一,刘怡潼,郭丞,陈天天,孙祖君,韩渤言,王浩歌,刘泳希,李晋晔,成炫忱,艾丽娅,陈瑶,李光复,王茂蕾,柳小海,姜超,佟磊,喻亢,李博,徐永革,贺美琦
0.02025更新至第16集主演:帕帕瓦迪·钱萨莫恩, 霍萨维·帕拉蓬皮善,Natharika Thamapreedanan,彭帕特·阿塔潘亚朋,普雷曼南·斯里帕尼,Eve Chaniporn Submee,阿梅娜·芘妮,琳雅乐·瓦查叻柔斯丽
0.02025更新至第12集主演:高伟光,梁靖康,张淼怡,毛晓慧,张宸逍,王宥钧,戴向宇,戴蕥琪,古子成,何雨虹,汤梦佳,厉嘉琪,赵尧珂,彭楚粤,姬晓飞,王伊瑶,姚一奇,宋涵宇,沈浩,丁笑滢,刘萌萌,岳旸,费启鸣,翁虹,张琪,于谨维,魏子昕,杜奕衡,罗二羊,王建国
0.01995已完结主演:Bruce Boxleitner,Michael O'Hare,Claudia Christian,Jerry Doyle,Mira Furlan,Richard Biggs,Andrea Thompson,Bill Mumy,Jason Carter,Tracy Scoggins,Stephen Furst,Patricia Tallman,Peter Jurasik
0.01994已完结主演:Bruce Boxleitner,Michael O'Hare,Claudia Christian,Jerry Doyle,Mira Furlan,Richard Biggs,Andrea Thompson,Bill Mumy,Jason Carter,Tracy Scoggins,Stephen Furst,Patricia Tallman,Peter Jurasik,Andreas Katsulas,Jeff Conaway,Robert Rusler
0.01994已完结主演:Jerry Doyle,Mira Furlan,Claudia Christian
0.01996已完结主演:Bruce Boxleitner,Michael O'Hare,Claudia Christian,Jerry Doyle,Mira Furlan
0.01996已完结主演:安德鲁·布劳尔,理查德·贝尔泽,里德·戴蒙德,克拉克·约翰森,米歇尔·佛贝丝,亚非特·科托,梅丽莎·里奥,凯尔·赛科特,马克斯·佩利希
0.01996已完结主演:杰里·奥尔巴赫,本杰明·布拉特,埃帕莎·默克森,萨姆·沃特森,凯莉·洛维,Steven Hill
0.01996已完结主演:和久井映見,堤真一,高橋克典
0.01996已完结主演:菅野美穗,冈田义德,草刈正雄,川岛直美
0.01996已完结主演:吕颂贤,梁艺龄,何宝生,陈少霞,何美钿,鲍方,鲁振顺,王伟,郑柏麟,陈鸿烈,罗乐林,黎汉持,唐宁,刘江,李龙基,蔡国庆,朱铁和,郑家生,古明华,黎耀祥,陈荣峻,梁舜燕,罗兰,孙季卿
0.01996已完结主演:吕颂贤,梁艺龄,何宝生,陈少霞,何美钿,鲍方,鲁振顺,王伟,郑柏麟,陈鸿烈,罗乐林,黎汉持,唐宁,刘江,李龙基,蔡国庆,朱铁和,郑家生,古明华,黎耀祥,陈荣峻,梁舜燕,罗兰,孙季卿
0.01996已完结主演:崔秀钟,李成延,裴勇俊,崔智友,朴仁焕,孙贤周,赵卿焕,车太贤
0.01996已完结主演:金喜善,李昌勋,金永爱,郑栋焕
0.01996已完结主演:裴勇俊,李英爱,车太贤,李惠英,朴中贤
0.01996已完结主演:安东尼·爱德华兹,乔治·克鲁尼,雪莉·斯蒂琳费尔德
0.01996已完结主演:大卫·杜楚尼,吉莲·安德森,米彻·佩勒吉,威廉·B·戴维斯,布莱恩·汤普森,史蒂文·威廉姆斯,劳瑞·侯登,莫里斯·潘迟,布雷丹·贝塞尔


